International Journal of Biological Sciences
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Editor-in-Chief: Dennis D. Taub, Chief of Clinical Immunology Section, Laboratory of Immunology, NIA, NIH
Editor-in-Chief's Profile
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- Indexed in MEDLINE, PubMed, EMBASE, CAS, CAB Abstracts, Scopus, Google Scholar and other databases.
- Full texts of articles appear in PubMed
Central and UK PubMed
Central
 .
- International exposure
and open access policy ensuring maximum distribution of scientific
results.
- Rapid peer-review and publication.
- (For NIH-funded researchers) No separated steps are necessary to comply with NIH Public Access Requirement. This journal deposits articles to PMC without author involvement.
- Visibility of full text article in Google and other search engines.
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| Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Previous proteomic evidence revealed that the content of certain peptide fragments including Vgf-derived peptide aa 398-411 (Vgf398-411) of the precursor Vgf protein in the cerebral spinal fluid (CSF) correctly identified patients with ALS from normal and disease controls. Using quantitative ELISA immunoassay we found that the CSF levels of Vgf decreases with muscle weakness in patients with ALS. In SOD1 G93A transgenic mice, loss of full-length Vgf content in CSF, serum and in SMI-32 immunopositive spinal cord motor neurons is noted in asymptomatic animals ...more |
| Anagrelide is often used in the treatment of thrombocythemia in myeloproliferative disease (MPD), but information concerning effects of treatment on cytokines involved in regulation of blood platelet levels is limited. Here, we investigated serum levels of thrombopoietin (TPO) and soluble IL-6 receptor (sIL-6R) in relation to response to treatment with and plasma concentrations of anagrelide. ...more |
| Micro RNAs (miRNAs) are 19-24 nucleotide long non-coding RNAs that posttranscriptionally modulate gene expression. They are found in almost all species: viruses, plants, nematodes, fly, fish, mouse, human, and are implicated in a wide array of cellular and developmental processes. Microarray-based miRNA profiling brought to the discovery of miRNAs specific to different hematopoietic lineages. ... more |
| Resting electrocardiogram (ECG) shows limited sensitivity and specificity for the detection of coronary artery disease (CAD), where patients with a history of coronary revascularization may pose special challenges. Several methods exist to enhance sensitivity and specificity of resting ECG for diagnosis of CAD, but such methods are not better than a specialist's judgement. We compared a new computer-enhanced, resting ECG analysis device, 3DMP, to coronary angiography to evaluate the device's accuracy in detecting hemodynamically relevant CAD.
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| Radiation quality indices (QI), tumor control probability (TCP), and normal tissue complication probability(NTCP) were evaluated for ideal single and double plane HDR interstitial implants. In the analysis, geometrically–optimized at volume (GOV) treatment plans were generated for different values of inter–source–spacing (ISS) within the catheter, inter–catheter–spacing (ICS), and inter–plane–spacing (IPS) for single - and double - plane implants. The dose volume histograms (DVH) were generated for each plan, and the coverage volumes of 100%, 150%, and 200% were obtained to calculate QIs, TCP, and NTCP. Formulae for biologically effective equivalent uniform dose (BEEUD), for tumor and normal tissues, were derived to calculate TCP and NTCP. ... more |
| Background: As aromatase-deficient mice, which are deficient in estrogens, reportedly have reduced blood pressure, the aromatase gene (CYP19A1) is thought to be a susceptibility gene for essential hypertension (EH). The aim of the present study was to investigate the relationship between CYP19A1 and EH by examining single nucleotide polymorphisms (SNPs). Methods: Five SNPs in the human CYP19A1 gene (rs1870049, rs936306, rs700518, rs10046 and rs4646) were selected, and an association study was performed in 218 Japanese EH patients and 225 age-matched normotensive (NT) individuals. ... more |
| Human Toll-like receptors (TLRs) comprise a family of proteins that recognizes pathogen-associated molecular patterns (PAMPs) and initiates host innate immune responses. Neutrophils, monocytes, and macrophages are critical cellular components of the human innate immune system. Proinflammatory cytokines, such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interferon-γ (IFN-γ), have been shown to up-regulate microbicidal activity in these effector cells of innate immunity. Currently, the cellular and molecular mechanisms responsible for these effects are not completely understood. We hypothesized that these cytokines may up-regulate TLR expression as a mechanism to facilitate microbial recognition and augment the innate immune response. ...more |
 A peer-reviewed journal publishes papers of significance in all areas of medical sciences. Articles include original research
papers, reviews and short research communications. Submissions of basic
and clinical research are both considered.
Recent articles:
Breast cancer screening in France: results of the EDIFICE survey
X Pivot, O Rixe, JF Morere, Y Coscas, L Cals, M Namer, D Serin, S Dolbeault, F Eisinger, C Roussel, JY Blay
Int. J. Med. Sci. 2008, 5: 106-112
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MAINTENANCE HORMONAL TREATMENT IMPROVES PROGRESSION FREE SURVIVAL AFTER A FIRST LINE CHEMOTHERAPY IN PATIENTS WITH METASTATIC BREAST CANCER
Armelle Dufresne, Xavier Pivot, Christophe Tournigand, Thomas Facchini, Thierry Alweeg, Loic Chaigneau, Aimery De Gramont
Int. J. Med. Sci. 2008, 5: 100-105
[Abstract]
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Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis
Zhong Zhao, Dale J. Lange, Lap Ho, Sara Bonini, Belinda Shao, Stephen R. Salton, Sunil Thomas, Giulio Maria Pasinetti
Int. J. Med. Sci. 2008, 5: 92-99
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TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders
Jan Palmblad, Magnus Björkholm, Jack Kutti, Gerd Lärfars, Eva Löfvenberg, Berit Markevärn, Mats Merup, Nils Mauritzson, Jan Westin, Jan Samuelsson, Gunnar Birgegård
Int. J. Med. Sci. 2008, 5: 87-91
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VEGF T-1498C polymorphism, a predictive marker of differentiation of colorectal adenocarcinomas in Japanese
Motohiro Yamamori, Mayuko Taniguchi, Shingo Maeda, Tsutomu Nakamura, Noboru Okamura, Akiko Kuwahara, Koichi Iwaki, Takao Tamura, Nobuo Aoyama, Svetlana Markova, Masato Kasuga, Katsuhiko Okumura, Toshiyuki Sakaeda
Int. J. Med. Sci. 2008, 5: 80-86
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Expression and function of micro RNAs in immune cells during normal or disease state
Esmerina Tili, Jean-Jacques Michaille, George Adrian Calin
Int. J. Med. Sci. 2008, 5: 73-79
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Principal Investigator Views of the IRB System
Simon N. Whitney, Kirsten Alcser, Carl E. Schneider, Laurence B. McCullough, Amy L. McGuire, Robert J. Volk
Int. J. Med. Sci. 2008, 5: 68-72
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A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy
Basir Tareen, Jack L. Summers, James M. Jamison, Deborah R. Neal, Karen McGuire, Lowell Gerson, Ananias Diokno
Int. J. Med. Sci. 2008, 5: 62-67
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Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis after coronary revascularization
Eberhard Grube, Andreas Bootsveld, Lutz Buellesfeld, Seyrani Yuecel, Joseph T Shen, Michael Imhoff
Int. J. Med. Sci. 2008, 5: 50-61
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Qualitative Dosimetric and Radiobiological Evaluation of High – Dose – Rate Interstitial brachytherapy Implants
Than S. Kehwar, Syed F. Akber, Kamlesh Passi
Int. J. Med. Sci. 2008, 5: 41-49
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Correlation of the Radiographic and Morphological Features of the Dental Follicle of Third Molars with Incomplete Root Formation
David Moraes de OLIVEIRA, Emanuel Sávio de Souza ANDRADE, Márcia Maria Fonseca da SILVEIRA, Igor Batista CAMARGO
Int. J. Med. Sci. 2008, 5: 36-40
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Association Study of Aromatase Gene (CYP19A1) in Essential Hypertension
Masanori Shimodaira, Tomohiro Nakayama, Naoyuki Sato, Kosuke Saito, Akihiko Morita, Ichiro Sato, Teruyuki Takahashi, Masayoshi Soma, Yoichi Izumi
Int. J. Med. Sci. 2008, 5: 29-35
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Physical Exercise and Quality of Life in Breast Cancer Survivors
Marco VALENTI, Giampiero PORZIO, Federica AIELLI, Lucilla VERNA, Katia CANNITA, Renato MANNO, Francesco MASEDU, Paolo MARCHETTI, Corrado FICORELLA
Int. J. Med. Sci. 2008, 5: 24-28
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Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema
Pedro J Modrego, Beatriz Boned, Juan J Berlanga, Mercedes Serrano
Int. J. Med. Sci. 2008, 5: 18-23
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Does eGFR improve the diagnostic capability of S-Creatinine concentration results? A retrospective population based study
Anders Kallner, Peter A Ayling, Zahra Khatami
Int. J. Med. Sci. 2008, 5: 9-17
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Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages
D. Shane O'Mahony, Uyenvy Pham, Ramesh Iyer, Thomas R. Hawn, W. Conrad Liles
Int. J. Med. Sci. 2008, 5: 1-8
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Association of Adiposity, Cardiorespiratory Fitness and Exercise Practice with the Prevalence of Type 2 Diabetes in Brazilian Elderly Women
Maressa P. Krause, Tatiane Hallage, Mirnaluci Paulino Ribeiro Gama, Fredric L. Goss, Robert Robertson, Sergio G. da Silva
Int. J. Med. Sci. 2007, 4: 288-292
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